The record for April 21 in baseball history — 10 milestones, 53 debuts, 10 final games, 47 births, 30 deaths and 1,117 games played.
Philip Humber threw a perfect game for the Chicago White Sox against the Seattle Mariners on April 21, 2012, winning 4–0.
Don Demeter hit three home runs for the Los Angeles Dodgers against the San Francisco Giants on April 21, 1959.
Willie Stargell hit three home runs for the Pittsburgh Pirates against the Atlanta Braves on April 21, 1971.
Tim Foli hit for the cycle for the Montreal Expos against the Chicago Cubs on April 21, 1976.
Milwaukee Brewers reliever Rollie Fingers records his 300th career save, the first pitcher in Major League history to reach the mark.
Jeff Bagwell hit three home runs for the Houston Astros against the Chicago Cubs on April 21, 1999.
Mike Lowell hit three home runs for the Florida Marlins against the Philadelphia Phillies on April 21, 2004.
Alfonso Soriano hit three home runs for the Washington Nationals against the Atlanta Braves on April 21, 2006.
Philip Humber threw a perfect game for the Chicago White Sox against the Seattle Mariners on April 21, 2012, winning 4–0.
Jake Arrieta threw a no-hitter for the Chicago Cubs against the Cincinnati Reds on April 21, 2016, winning 16–0.
Sean Manaea threw a no-hitter for the Oakland Athletics against the Boston Red Sox on April 21, 2018, winning 3–0.
Fred Warner made a major-league debut on April 21, 1875.
Duke Farrell made a major-league debut on April 21, 1888.
Steve Brodie made a major-league debut on April 21, 1890.
Crazy Schmit made a major-league debut on April 21, 1890.
Ed Gremminger made a major-league debut on April 21, 1895.
Bill Duggleby made a major-league debut on April 21, 1898.
John Ganzel made a major-league debut on April 21, 1898.
Ginger Beaumont made a major-league debut on April 21, 1899.
Deacon Phillippe made a major-league debut on April 21, 1899.
Cy Falkenberg made a major-league debut on April 21, 1903.
Hooks Wiltse made a major-league debut on April 21, 1904.
Pat Ragan made a major-league debut on April 21, 1909.
Shano Collins made a major-league debut on April 21, 1910.
Joe Oeschger made a major-league debut on April 21, 1914.
Mike McNally made a major-league debut on April 21, 1915.
Jumbo Elliott made a major-league debut on April 21, 1923.
Curt Davis made a major-league debut on April 21, 1934.
Fritz Ostermueller made a major-league debut on April 21, 1934.
Ken O'Dea made a major-league debut on April 21, 1935.
Johnny Rigney made a major-league debut on April 21, 1937.
Max Macon made a major-league debut on April 21, 1938.
Merrill May made a major-league debut on April 21, 1939.
Ewell Blackwell made a major-league debut on April 21, 1942.
Eddie Stanky made a major-league debut on April 21, 1943.
Frankie Zak made a major-league debut on April 21, 1944.
Erv Palica made a major-league debut on April 21, 1945.
Jim Delsing made a major-league debut on April 21, 1948.
Roy Sievers made a major-league debut on April 21, 1949.
Connie Marrero made a major-league debut on April 21, 1950.
Dale Long made a major-league debut on April 21, 1951.
Harry Simpson made a major-league debut on April 21, 1951.
Ron Kline made a major-league debut on April 21, 1952.
Lee Walls made a major-league debut on April 21, 1952.
Hank Foiles made a major-league debut on April 21, 1953.
Paul Foytack made a major-league debut on April 21, 1953.
Jackie Brandt made a major-league debut on April 21, 1956.
Marty Keough made a major-league debut on April 21, 1956.
Don Cardwell made a major-league debut on April 21, 1957.
Tom Cheney made a major-league debut on April 21, 1957.
Steve Barber made a major-league debut on April 21, 1960.
Chuck Estrada made a major-league debut on April 21, 1960.
Walt Williams made a major-league debut on April 21, 1964.
Jody Davis made a major-league debut on April 21, 1981.
Kip Gross made a major-league debut on April 21, 1990.
Chris Jones made a major-league debut on April 21, 1991.
Hipólito Pichardo made a major-league debut on April 21, 1992.
Joe Nathan made a major-league debut on April 21, 1999.
Chad Tracy made a major-league debut on April 21, 2004.
Shin-Soo Choo made a major-league debut on April 21, 2005.
Drew Hutchison made a major-league debut on April 21, 2012.
Anthony Rendon made a major-league debut on April 21, 2013.
Carlos Rodón made a major-league debut on April 21, 2015.
Addison Russell made a major-league debut on April 21, 2015.
Frank Chance played a final major-league game on April 21, 1914.
Burt Shotton played a final major-league game on April 21, 1923.
Morrie Arnovich played a final major-league game on April 21, 1946.
Don Kolloway played a final major-league game on April 21, 1953.
Roy Smalley played a final major-league game on April 21, 1958.
Bob Thurman played a final major-league game on April 21, 1959.
Fran Healy played a final major-league game on April 21, 1978.
Dion James played a final major-league game on April 21, 1996.
Micah Bowie played a final major-league game on April 21, 2008.
Tomás Pérez played a final major-league game on April 21, 2008.
Tampa Bay Rays 4, New York Yankees 5.
Detroit Tigers 6, Minnesota Twins 1.
Baltimore Orioles 5, Kansas City Royals 0.
Oakland Athletics 2, Cleveland Guardians 6.
Toronto Blue Jays 0, Houston Astros 7.
San Diego Padres 4, Detroit Tigers 6.
New York Yankees 4, Cleveland Guardians 6.
Chicago White Sox 2, Boston Red Sox 4.
Milwaukee Brewers 2, San Francisco Giants 5.
Philadelphia Phillies 4, New York Mets 5.
Cincinnati Reds 3, Miami Marlins 6.
St. Louis Cardinals 6, Atlanta Braves 7.
These are the 12 most recent of 1,117 games played on this date. The sections above lead with what made the day matter.
47 players were born on April 21; these are the 24 best known.
30 players died on April 21; these are the 24 best known.