Vladimir Guerrero's Three-Home-Run Game, 2022

Vladimir Guerrero hit three home runs in one game for the Toronto Blue Jays against the New York Yankees on April 13, 2022. The Toronto Blue Jays won 6–4.

The game was played at Yankee Stadium II in New York. The announced attendance was 30,109. The game took 3h 10m. It was a night game under cloudy skies, at 65 degrees.

Vladimir Guerrero did it twice in all. Gerrit Cole started for the New York Yankees. Bruce Dreckman umpired behind the plate. It is the first of fourteen three-home-run games the archive records that season.