Isaac Paredes's Three-Home-Run Game, 2022

Isaac Paredes hit three home runs in one game for the Tampa Bay Rays against the New York Yankees on June 21, 2022. The Tampa Bay Rays won 5–4.

The game was played at Tropicana Field in St. Petersburg. The announced attendance was 20,688. The game took 2h 42m. It was a night game indoors, at 72 degrees.

It was the only time Isaac Paredes managed it. Néstor Cortés started for the New York Yankees. Marvin Hudson umpired behind the plate. It is the ninth of fourteen three-home-run games the archive records that season.