Brandon Lowe's Three-Home-Run Game, 2021

Brandon Lowe hit three home runs in one game for the Tampa Bay Rays against the New York Yankees on October 2, 2021. The Tampa Bay Rays won 12–2.

The game was played at Yankee Stadium II in New York. The announced attendance was 41,648. The game took 3h 26m. It was a day game under cloudy skies, at 73 degrees.

It was the only time Brandon Lowe managed it. Jordan Montgomery started for the New York Yankees. Lance Barksdale umpired behind the plate. It is the last of fourteen three-home-run games the archive records that season.