Albert Pujols's Three-Home-Run Game, 2006

Albert Pujols hit three home runs in one game for the St. Louis Cardinals against the Cincinnati Reds on April 16, 2006. The St. Louis Cardinals won 8–7.

The game was played at Busch Stadium III in St. Louis. The announced attendance was 40,068. The game took 3h 04m. It was a day game under sunny skies, at 82 degrees.

Albert Pujols did it four times in all. Bronson Arroyo started for the Cincinnati Reds. Joe Brinkman umpired behind the plate. It is the first of eleven three-home-run games the archive records that season.