Dominic Canzone's Three-Home-Run Game, 2025

Dominic Canzone hit three home runs in one game for the Seattle Mariners against the Kansas City Royals on September 16, 2025. The Seattle Mariners won 12–5.

The game was played at Kauffman Stadium in Kansas City. The announced attendance was 20,017. The game took 2h 55m. It was a night game under cloudy skies, at 89 degrees.

It was the only time Dominic Canzone managed it. Michael Wacha started for the Kansas City Royals. Chad Fairchild umpired behind the plate. It is the fourteenth of 16 three-home-run games the archive records that season.